Fluconazole induced Stevens-Johnson Syndrome Leading to the Diagnosis of HIV Infection
Published: December 1, 2019 | DOI: https://doi.org/10.7860/JCDR/2019/42126.13338
Prafulla Kumar Sharma, Soumya Sachdeva, Konchok Dorjay, Devika Choudhry
1. Professor, Department of Dermatology, Venereology and Leprosy, PGIMER and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
2. Junior Resident PG (2nd year), Department of Dermatology, Venereology and Leprosy, PGIMER and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
3. Senior Resident, Department of Dermatology, Venereology and Leprosy, PGIMER and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
4. Junior Resident, PG (3rd year), Department of Dermatology, Venereology and Leprosy, PGIMER and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Correspondence
Dr. Soumya Sachdeva,
Flat No. 16, Jawahar Apartments, GH-54, Sector 56, Gurugram-122011, Haryana, India.
E-mail: soumyasachdeva1402@gmail.com
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are adverse cutaneous drug reaction that has been associated with various drugs like antibiotics, anticonvulsant and non-steroidal anti-inflammatory agents. Fluconazole has rarely been associated with SJS and TEN. A 39-year-old male case of SJS due to Fluconazole, who was subsequently diagnosed to suffer from Acquired Immunodeficiency Syndrome (AIDS) is being reported. The low CD4+ T Cell count in this patient is a likely contributing factor for the precipitation of SJS due to Fluconazole. There is a paucity of reports of SJS due to fluconazole in HIV positive patients, though TEN has been described in few patients. This case highlights that Fluconazole causing SJS/TEN is more likely in a HIV positive patient. This patient’s HIV positive status was diagnosed subsequent to the diagnosis of SJS.
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